Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.

ABSTRACT:

Purpose

Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI).

Methods

In a prospective nested case-control study of 1,331 white patients with PCa and 1,267 age-matched controls, we examined associations of five common SNPs within FASN (and 5 kb upstream/downstream, R(2) > 0.8) with PCa incidence and, among patients, PCa-specific death and tested for an interaction with BMI. Survival analyses were repeated for tumor FASN expression (n = 909).

Results

Four of the five SNPs were associated with lethal PCa. SNP rs1127678 was signifi

SUBMITTER: Nguyen PL 

PROVIDER: S-EPMC2940394 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature