Amphiregulin promotes intestinal epithelial regeneration: roles of intestinal subepithelial myofibroblasts.

ABSTRACT: Epidermal growth factor family plays critical roles in intestinal epithelial proliferation and differentiation. The precise function of amphiregulin (AREG), a member of the epidermal growth factor family, in intestinal biology is largely unknown. The present study attempted to address the functional roles of AREG in intestinal epithelial regeneration. Total body irradiation was performed, and intestinal regeneration was assessed in AREG knockout mice. Genetically disruption of AREG significantly impaired intestinal regeneration after radiation injury. It is known that prostaglandin E(2) (PGE(2)) exerts radio-protective and growth-stimulatory effects on intestinal epithelium. We found that PGE(2) radio-protective action did not involve AREG. However, PGE(2) growth-stimulatory effects requir

SUBMITTER: Shao J 

PROVIDER: S-EPMC2940516 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature