The cognitive effects of conjugated equine estrogens depend on whether menopause etiology is transitional or surgical.

ABSTRACT: The question of whether to take hormone therapy (HT) will impact every woman as she enters reproductive senescence. In women, studies suggest that ovarian hormone loss associated with menopause has deleterious cognitive effects. Results from clinical studies evaluating whether estrogen-containing HT mitigates these effects, and benefits cognition, are discrepant. Type of menopause, surgical vs. transitional, impacts cognitive outcome in women. However, whether type of menopause impacts cognitive effects of HT has not been methodically tested in women or an animal model. We used the 4-vinylcyclohexene diepoxide rodent model of ovarian follicle depletion, which mimics transitional menopause, and the traditional rat model of menopause, ovariectomy, to cognitively test the most commonly prescr

SUBMITTER: Acosta JI 

PROVIDER: S-EPMC2940533 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature