SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease.

ABSTRACT: Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likely to uncover genetic factors that influence progression of disease. An alternative approach to identifying genetic risk for AD is the use of quantitative traits or endophenotypes. The use of endophenotypes has proven to be an effective strategy, implicating genetic risk factors in several diseases, including anemia, osteoporosis and heart disease. In this study we identify a genetic factor associated with the rate of decline in AD patients and present a methodology for identification of other such factors. We have used an established biomarker for AD, cerebrospinal fluid (CSF)

SUBMITTER: Cruchaga C 

PROVIDER: S-EPMC2940763 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature