E-selectin gene polymorphisms are associated with essential hypertension: a case-control pilot study in a Chinese population.

ABSTRACT:

Background

Genetic variation is thought to contribute to the etiology of hypertension, and E-selectin is a candidate essential hypertension-associated gene. This study thus sought to investigate possible genetic associations between the T1880C, C602A and T1559C polymorphisms of E-selectin and essential hypertension.

Methods

Hypertensive patients (n = 490) and healthy normotensive subjects (n = 495) were screened for the genotypes T1880C, C602A and T1559C using real-time quantitative polymerase chain reaction after DNA extraction to identify representative variations in the E-selectin gene. The associations between genotypes and alleles of the three mutations and essential hypertension were then analyzed using a case-control study.

Results

Hypertensive patients and nor

SUBMITTER: Wang Z 

PROVIDER: S-EPMC2940768 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature