Important role of indels in somatic mutations of human cancer genes.

ABSTRACT:

Background

Cancer is clonal proliferation that arises owing to mutations in a subset of genes that confer growth advantage. More and more cancer related genes are found to have accumulated somatic mutations. However, little has been reported about mutational patterns of insertions/deletions (indels) in these genes.

Results

We analyzed indels' abundance and distribution, the relative ratio between indels and somatic base substitutions and the association between those two forms of mutations in a large number of somatic mutations in the Catalogue of Somatic Mutations in Cancer database. We found a strong correlation between indels and base substitutions in cancer-related genes and showed that they tend to concentrate at the same locus in the coding sequences within the same sa

SUBMITTER: Yang H 

PROVIDER: S-EPMC2940769 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature