Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate?

ABSTRACT: After the hope and controversy brought by embryonic stem cells two decades ago for regenerative medicine, a new turn has been taken in pluripotent cells research when, in 2006, Yamanaka's group reported the reprogramming of fibroblasts to pluripotent cells with the transfection of only four transcription factors. Since then many researchers have managed to reprogram somatic cells from diverse origins into pluripotent cells, though the cellular and genetic consequences of reprogramming remain largely unknown. Furthermore, it is still unclear whether induced pluripotent stem cells (iPSCs) are truly functionally equivalent to embryonic stem cells (ESCs) and if they demonstrate the same differentiation potential as ESCs. There are a large number of reprogramming experiments published so far en

SUBMITTER: Boue S 

PROVIDER: S-EPMC2941458 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature