Evaluation of the thyroid in patients with hearing loss and enlarged vestibular aqueducts.

ABSTRACT:

Objective

To evaluate thyroid structure and function in patients with enlargement of the vestibular aqueduct (EVA) and sensorineural hearing loss.

Design

Prospective cohort survey.

Setting

National Institutes of Health Clinical Center, a federal biomedical research facility.

Patients

The study population comprised 80 individuals, aged 1.5 to 59 years, ascertained on the basis of EVA and sensorineural hearing loss.

Main outcome measures

Associations among the number of mutant alleles of SLC26A4; volume and texture of the thyroid; percentage of iodine 123 ((123)I) discharged at 120 minutes after administration of perchlorate in the perchlorate discharge test; and peripheral venous blood levels of thyrotropin, thyroxine, free thyroxine, triiodothyronine, th

SUBMITTER: Madeo AC 

PROVIDER: S-EPMC2941509 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature