HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.

ABSTRACT: The search for longevity-determining genes in human has largely neglected the operation of genetic interactions. We have identified a novel combination of common variants of three genes that has a marked association with human lifespan and healthy aging. Subjects were recruited and stratified according to their genetically inferred ethnic affiliation to account for population structure. Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity. An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population. A profile of healthy aging was developed using a deficit accumulation

SUBMITTER: Jazwinski SM 

PROVIDER: S-EPMC2941558 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature