Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development.

ABSTRACT:

Background

In sensory systems with broad bandwidths, polarized receptor cells utilize highly specialized organelles in their apical and basolateral compartments to transduce and ultimately transmit signals to the rest of the nervous system. While progress has been made in elucidating the assembly of the transduction apparatus, the development of synaptic ribbon-containing terminals remains poorly understood. To begin to delineate the targeting of the exocytotic machinery specifically in ribbon-containing neurons, we have examined the expression of complexins 3 and 4 in the zebrafish visual and acousticolateral systems during the first week of development.

Results

We have identified five members of the complexin 3/4 subfamily in zebrafish that show 50 to 75% amino acid identi

SUBMITTER: Zanazzi G 

PROVIDER: S-EPMC2941751 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature