Identification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation.

ABSTRACT:

Background

Many evidences report that alternative splicing, the mechanism which produces mRNAs and proteins with different structures and functions from the same gene, is altered in cancer cells. Thus, the identification and characterization of cancer-specific splice variants may give large impulse to the discovery of novel diagnostic and prognostic tumour biomarkers, as well as of new targets for more selective and effective therapies.

Results

We present here a genome-wide analysis of the alternative splicing pattern of human genes through a computational analysis of normal and cancer-specific ESTs from seventeen anatomical groups, using data available in AspicDB, a database resource for the analysis of alternative splicing in human. By using a statistical methodology, norm

SUBMITTER: Valletti A 

PROVIDER: S-EPMC2941758 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature