Serotonin synthesis, release and reuptake in terminals: a mathematical model.

ABSTRACT:

Background

Serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders. Full understanding of serotonergic systems in the central nervous system involves genomics, neurochemistry, electrophysiology, and behavior. Though associations have been found between functions at these different levels, in most cases the causal mechanisms are unknown. The scientific issues are daunting but important for human health because of the use of selective serotonin reuptake inhibitors and other pharmacological agents to treat disorders in the serotonergic signaling system.

Methods

We construct a mathema

SUBMITTER: Best J 

PROVIDER: S-EPMC2942809 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature