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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

ABSTRACT: We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

SUBMITTER: Perry JR 

PROVIDER: S-EPMC2942986 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

Perry John R B JR   Stolk Lisette L   Franceschini Nora N   Lunetta Kathryn L KL   Zhai Guangju G   McArdle Patrick F PF   Smith Albert V AV   Aspelund Thor T   Bandinelli Stefania S   Boerwinkle Eric E   Cherkas Lynn L   Eiriksdottir Gudny G   Estrada Karol K   Ferrucci Luigi L   Folsom Aaron R AR   Garcia Melissa M   Gudnason Vilmundur V   Hofman Albert A   Karasik David D   Kiel Douglas P DP   Launer Lenore J LJ   van Meurs Joyce J   Nalls Michael A MA   Rivadeneira Fernando F   Shuldiner Alan R AR   Singleton Andrew A   Soranzo Nicole N   Tanaka Toshiko T   Visser Jenny A JA   Weedon Michael N MN   Wilson Scott G SG   Zhuang Vivian V   Streeten Elizabeth A EA   Harris Tamara B TB   Murray Anna A   Spector Tim D TD   Demerath Ellen W EW   Uitterlinden André G AG   Murabito Joanne M JM  

Nature genetics 20090517 6

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. ...[more]

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