Structure/function relationships of apolipoprotein a-I mimetic peptides: implications for antiatherogenic activities of high-density lipoprotein.

ABSTRACT:

Rationale

Apolipoprotein (apoA)-I mimetic peptides are a promising type of anti-atherosclerosis therapy, but how the structural features of these peptides relate to the multiple antiatherogenic functions of HDL is poorly understood.

Objective

To establish structure/function relationships of apoA-I mimetic peptides with their antiatherogenic functions.

Methods and results

Twenty-two bihelical apoA-I mimetic peptides were investigated in vitro for the capacity and specificity of cholesterol efflux, inhibition of inflammatory response of monocytes and endothelial cells, and inhibition of low-density lipoprotein (LDL) oxidation. It was found that mean hydrophobicity, charge, size of hydrophobic face, and angle of the link between the helices are the major factors determin

SUBMITTER: D'Souza W 

PROVIDER: S-EPMC2943235 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature