A new method to account for missing data in case-parent triad studies.

ABSTRACT:

Background/aims

The case-parent triad design is commonly used in genetic association studies. Generally, samples are drawn from an affected offspring, manifesting a phenotype of interest, as well as from the parents. The trio genotypes may be analyzed using a variety of available methods, but we focus on log-linear models because they test for genetic association and additionally estimate the relative risks of transmission. The models need to be modified to adjust for missing genotypes. Furthermore, instability in the parameter estimates can arise when certain kinds of genotype combinations do not appear in the dataset.

Methods

In this paper, we kill two birds with one stone. We propose a new method to simultaneously account for missing genotype data and genotype combination

SUBMITTER: Bergemann TL 

PROVIDER: S-EPMC2943516 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature