Molecular modeling-based evaluation of hTLR10 and identification of potential ligands in Toll-like receptor signaling.

ABSTRACT: Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogens based on distinct molecular signatures. The human (h)TLR1, 2, 6 and 10 belong to the hTLR1 subfamilies, which are localized in the extracellular regions and activated in response to diverse ligand molecules. Due to the unavailability of the hTLR10 crystal structure, the understanding of its homo and heterodimerization with hTLR2 and hTLR1 and the ligand responsible for its activation is limited. To improve our understanding of the TLR10 receptor-ligand interaction, we used homology modeling to construct a three dimensional (3D) structure of hTLR10 and refined the model through molecular dynamics (MD) simulations. We utilized the optimized structures for the molecular docking in order to identify the poten

SUBMITTER: Govindaraj RG 

PROVIDER: S-EPMC2943521 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature