Mathematical modelling of whole chromosome replication.

ABSTRACT: All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins. Here we investigate how the activity of multiple origins on each chromosome is coordinated to ensure successful replication. We present a stochastic model for whole chromosome replication where the dynamics are based upon the parameters of individual origins. Using this model we demonstrate that mean replication time at any given chromosome position is determined collectively by the parameters of all origins. Combining parameter estimation with extensive simulations we show that there is a range of model parameters consistent with mean replication data, emphasising the need for caution in interpreting su

SUBMITTER: de Moura AP 

PROVIDER: S-EPMC2943597 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature