Randomized trial of pulmonary valve replacement with and without right ventricular remodeling surgery.

ABSTRACT:

Background

Although pulmonary valve replacement (PVR) is effective in reducing right ventricular (RV) volume overload in patients with chronic pulmonary regurgitation, persistent RV dysfunction and subsequent adverse clinical outcomes have been reported. This trial was conducted to investigate whether the addition of surgical RV remodeling with exclusion of scar tissue to PVR would result in improved RV function and laboratory and clinical parameters, as compared with PVR alone.

Methods and results

Between February 2004 and October 2008, 64 patients who underwent RV outflow tract procedures in early childhood had more than or equal to moderate pulmonary regurgitation, and fulfilled defined criteria for PVR were randomly assigned to undergo either PVR alone (n=34) or PVR with

SUBMITTER: Geva T 

PROVIDER: S-EPMC2943672 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature