Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery.

ABSTRACT:

Background

Recent genome-wide association studies have identified several chromosome 9p21 single nucleotide polymorphisms associated with coronary artery disease and myocardial infarction in nonsurgical populations. We have recently demonstrated an independent association between these 9p21 variants and perioperative myocardial injury after isolated primary coronary artery bypass graft (CABG) surgery. This study investigated the association of a 9p21 variant with mortality in patients after CABG surgery and its prognostic value to improve the EuroSCORE.

Methods and results

In a 2-center, prospective, observational study of 846 white primary CABG surgery patients, we genotyped rs10116277, the 9p21 variant with the strongest association to perioperative myocardial injury in ou

SUBMITTER: Muehlschlegel JD 

PROVIDER: S-EPMC2943860 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature