Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis.

ABSTRACT:

Purpose

Current evidence indicates that an osteoblast lesion in prostate cancer is preceded by osteolysis. Thus, prevention of osteolysis would reduce complications of bone metastasis. Bone marrow-derived mesenchymal stem cells have the ability to differentiate into osteoblast and produce osteoprotegerin, a decoy receptor for the receptor activator for nuclear factor kappaB ligand, naturally. The present study examined the potential of unmodified mesenchymal stem cells to prevent osteolytic bone lesions in a preclinical mouse model of prostate cancer.

Experimental design

The human prostate cancer cell line PC3 was implanted in tibiae of severe combined immunodeficient mice. After establishment of the tumor, either unmodified or genetically engineered mesenchymal stem cells o

SUBMITTER: Chanda D 

PROVIDER: S-EPMC2943933 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature