Context dependence and coevolution among amino acid residues in proteins.

ABSTRACT: As complete genomes accumulate and the generation of genomic biodiversity proceeds at an accelerating pace, the need to understand the interaction between sequence evolution and protein structure and function rises in prominence. The pattern and pace of substitutions in proteins can provide important clues to functional importance, functional divergence, and adaptive response. Coevolution between amino acid residues and the context dependence of the evolutionary process are often ignored, however, because of their complexity, but they are critical for the accurate interpretation of reconstructed evolutionary events. Because residues interact with one another, and because the effect of substitutions can depend on the structural and physiological environment in which they occur, an accurate

SUBMITTER: Wang ZO 

PROVIDER: S-EPMC2943952 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature