A yeast's eye view of mammalian reproduction: cross-species gene co-expression in meiotic prophase.

ABSTRACT:

Background

Meiotic prophase is a critical stage in sexual reproduction. Aberrant chromosome recombination during this stage is a leading cause of human miscarriages and birth defects. However, due to the experimental intractability of mammalian gonads, only a very limited number of meiotic genes have been characterized. Here we aim to identify novel meiotic genes important in human reproduction through computational mining of cross-species and cross-sex time-series expression data from budding yeast, mouse postnatal testis, mouse embryonic ovary, and human fetal ovary.

Results

Orthologous gene pairs were ranked by order statistics according to their co-expression profiles across species, allowing us to infer conserved meiotic genes despite obvious differences in cellular syn

SUBMITTER: Li Y 

PROVIDER: S-EPMC2944139 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature