Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation.

ABSTRACT:

Background

The trophoblast lineage arises as the first differentiation event during embryogenesis. Trophoblast giant cells are one of several end-stage products of trophoblast cell differentiation in rodents. These cells are located at the maternal-fetal interface and are capable of invasive and endocrine functions, which are necessary for successful pregnancy. Rcho-1 trophoblast stem cells can be effectively used as a model for investigating trophoblast cell differentiation. In this report, we evaluated the role of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in the regulation of trophoblast cell differentiation. Transcript profiles from trophoblast stem cells, differentiated trophoblast cells, and differentiated trophoblast cells following disruption of PI3K signali

SUBMITTER: Kent LN 

PROVIDER: S-EPMC2944162 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature