Phylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia.

ABSTRACT:

Background

Dengue Fever is one of the most important viral re-emergent diseases affecting about 50 million people around the world especially in tropical and sub-tropical countries. In Colombia, the virus was first detected in the earliest 70's when the disease became a major public health concern. Since then, all four serotypes of the virus have been reported. Although most of the huge outbreaks reported in this country have involved dengue virus serotype 1 (DENV-1), there are not studies about its origin, genetic diversity and distribution.

Results

We used 224 bp corresponding to the carboxyl terminus of envelope (E) gene from 74 Colombian isolates in order to reconstruct phylogenetic relationships and to estimate time divergences. Analyzed DENV-1 Colombian isolates belong

SUBMITTER: Mendez JA 

PROVIDER: S-EPMC2944171 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature