Environment and vascular bed origin influence differences in endothelial transcriptional profiles of coronary and iliac arteries.

ABSTRACT: Atherosclerotic plaques tend to form in the major arteries at certain predictable locations. As these arteries vary in atherosusceptibility, interarterial differences in endothelial cell biology are of considerable interest. To explore the origin of differences observed between typical atheroprone and atheroresistant arteries, we used DNA microarrays to compare gene expression profiles of harvested porcine coronary (CECs) and iliac artery endothelial cells (IECs) grown in static culture out to passage 4. Fewer differences were observed between the transcriptional profiles of CECs and IECs in culture compared with in vivo, suggesting that most differences observed in vivo were due to distinct environmental cues in the two arteries. One-class significance of microarrays revealed that most in

SUBMITTER: Burridge KA 

PROVIDER: S-EPMC2944485 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature