Repair of DNA double-strand breaks following UV damage in three Sulfolobus solfataricus strains.

ABSTRACT: DNA damage repair mechanisms have been most thoroughly explored in the eubacterial and eukaryotic branches of life. The methods by which members of the archaeal branch repair DNA are significantly less well understood but have been gaining increasing attention. In particular, the approaches employed by hyperthermophilic archaea have been a general source of interest, since these organisms thrive under conditions that likely lead to constant chromosomal damage. In this work we have characterized the responses of three Sulfolobus solfataricus strains to UV-C irradiation, which often results in double-strand break formation. We examined S. solfataricus strain P2 obtained from two different sources and S. solfataricus strain 98/2, a popular strain for site-directed mutation by homologous recom

SUBMITTER: Rolfsmeier ML 

PROVIDER: S-EPMC2944543 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature