Characterization and PCR-based replicon typing of resistance plasmids in Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is an opportunistic pathogen, especially in intensive care units, and multidrug-resistant isolates have increasingly been reported during the last decade. Despite recent progress in knowledge of antibiotic resistance mechanisms in A. baumannii, little is known about the genetic factors driving isolates toward multidrug resistance. In the present study, the A. baumannii plasmids were investigated through the analysis and classification of plasmid replication systems and the identification of A. baumannii-specific mobilization and addiction systems. Twenty-two replicons were identified by in silico analysis, and five other replicons were identified and cloned from previously uncharacterized A. baumannii resistance plasmids carrying the OXA-58 carbapenem-hydrolyzing ox

SUBMITTER: Bertini A 

PROVIDER: S-EPMC2944597 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature