DMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells.

ABSTRACT: Genetic analyses in Drosophila epithelia have suggested that the phenomenon of "cell competition" could participate in organ homeostasis. It has been speculated that competition between different cell populations within a growing organ might play a role as either tumor promoter or tumor suppressor, depending on the cellular context. The evolutionarily conserved Hippo (Hpo) signaling pathway regulates organ size and prevents hyperplastic disease from flies to humans by restricting the activity of the transcriptional cofactor Yorkie (yki). Recent data indicate also that mutations in several Hpo pathway members provide cells with a competitive advantage by unknown mechanisms. Here we provide insight into the mechanism by which the Hpo pathway is linked to cell competition, by identifying dMyc

SUBMITTER: Ziosi M 

PROVIDER: S-EPMC2944792 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature