Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis.

ABSTRACT:

Background

Disorganized angiogenesis is associated with several pathologies, including cancer. The identification of new genes that control tumor neovascularization can provide novel insights for future anti-cancer therapies. Sprouty1 (SPRY1), an inhibitor of the MAPK pathway, might be one of these new genes. We identified SPRY1 by comparing the transcriptomes of untreated endothelial cells with those of endothelial cells treated by the angiostatic agent 16 K prolactin (16 K hPRL). In the present study, we aimed to explore the potential function of SPRY1 in angiogenesis.

Results

We confirmed 16 K hPRL induced up-regulation of SPRY1 in primary endothelial cells. In addition, we demonstrated the positive SPRY1 regulation in a chimeric mouse model of human colon carcinoma in wh

SUBMITTER: Sabatel C 

PROVIDER: S-EPMC2944818 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature