Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.

ABSTRACT:

Background

Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified according to extent and location of disease. The genetic susceptibility to CD is well known and genome-wide association scans (GWAS) and meta-analysis thereof have identified over 30 susceptibility loci. Except for the association between ileal CD and NOD2 mutations, efforts in trying to link CD genetics to clinical subphenotypes have not been very successful. We hypothesized that the large number of confirmed genetic variants enables (better) classification of CD patients.

Methodology/principal findings

To look for genetic-based subgroups, genotyping results of 46 SNPs identified from CD GWAS were analyzed by Latent Class Analysis (LCA) in CD patients and in healthy controls. Six g

SUBMITTER: Cleynen I 

PROVIDER: S-EPMC2944846 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature