Protective action of resveratrol in human skin: possible involvement of specific receptor binding sites.

ABSTRACT:

Background

Resveratrol is a plant-derived polyphenol with purported protecting action on various disorders associated with aging. It has been suggested that resveratrol could exert its protective action by acting on specific plasma membrane polyphenol binding sites (Han Y.S., et al. (2006) J Pharmacol Exp Ther 318:238-245). The purpose of this study was to investigate, in human skin, the possible existence of specific binding sites that mediate the protective action of resveratrol.

Methods and findings

Using human skin tissue, we report here the presence of specific [(3)H]-resveratrol binding sites (K(D)  =  180 nM) that are mainly located in the epidermis. Exposure of HaCaT cells to the nitric oxide free radical donor sodium nitroprusside (SNP; 0.3-3 mM) resulted in cell de

SUBMITTER: Bastianetto S 

PROVIDER: S-EPMC2944869 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature