The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage.

ABSTRACT:

Background

Requirements for human B lymphopoiesis are still poorly understood, and that has hampered investigation of differentiation events. For example, there are few cell surface antigens that can be used as milestones of lineage progression. The CD10 ectoenzyme is one such marker and has been used to define CLP, but we found substantial tissue specific variations in CD10 levels, and there was no information about how that corresponded to differentiation options.

Methodology/principal findings

The aim of the present study was to use recently developed culture methods to assess the nature and differentiation potential of progenitors sorted according to CD10 density from umbilical cord blood (CB), adult bone marrow (BM) or G-CSF mobilized peripheral blood (PB). Many CD34(+)

SUBMITTER: Ichii M 

PROVIDER: S-EPMC2944886 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature