Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells.

ABSTRACT:

Background

ATP-binding cassette (ABC) transporters protect cells against unrelated (toxic) substances by pumping them across cell membranes. Earlier we showed that many ABC transporters are highly expressed in hematopoietic stem cells (HSCs) compared to more committed progenitor cells. The ABC transporter expression signature may guarantee lifelong protection of HSCs but may also preserve stem cell integrity by extrusion of agents that trigger their differentiation. Here we have studied whether non-hematopoietic stem cells (non-HSCs) exhibit a similar ABC transporter expression signature as HSCs.

Results

ABC transporter expression profiles were determined in non-hematopoietic stem cells (non-HSCs) from embryonic, neonatal and adult origin as well as in various mature blood c

SUBMITTER: Tang L 

PROVIDER: S-EPMC2945345 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature