Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I.

ABSTRACT: We attempted to refine the understanding of an association of Y-chromosomal haplogroup I (hg-I) with enhanced AIDS progression that had been previously reported. First, we compared the progression phenotype between hg-I and its phylogenetically closest haplogroup J. Then, we took a candidate gene approach resequencing DDX3Y, a crucial autoimmunity gene, in hg-I and other common European Y-chromosome haplogroups looking for functional variants. We extended the genetic analyses to CD24L4 and compared and contrasted the roles of disease-based selection, demographic history and population structure shaping the contemporary genetic landscape of hg-I chromosomes. Our results confirmed and refined the AIDS progression signal to hg-I, though no gene variant was identified that can explain the dise

SUBMITTER: Sezgin E 

PROVIDER: S-EPMC2945452 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature