Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate.

ABSTRACT: The Notch-regulated transcription factor mouse atonal homolog 1 (Math1) is required for the development of intestinal secretory cells, as demonstrated by the loss of goblet, endocrine and Paneth cell types in null mice. However, it was unknown whether Math1 is sufficient to induce the program of secretory cell differentiation. To examine the function of Math1 in the differentiation of intestinal epithelial cells, intestinal morphology and epithelial and mesenchymal cell fate were examined by histological staining and marker gene expression in transgenic mice expressing a villin-regulated Math1 transgene. Late prenatal transgenic founders exhibited a gross cellular transformation into a secretory epithelium. The expansion of secretory cells coupled with the almost complete loss of absorptiv

SUBMITTER: VanDussen KL 

PROVIDER: S-EPMC2945455 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature