AXIS inhibition protein 2, orofacial clefts and a family history of cancer.

ABSTRACT:

Background

Cancer and congenital malformations occasionally may have a common etiology. The authors investigated whether families with one or more members affected by orofacial clefts (that is, families segregating orofacial clefts) had an increased cancer incidence when compared with control families.

Methods

The authors assessed 75 white families with nonsyndromic cleft lip with or without cleft palate (CL/P) and 93 white control families regarding a history of cancer. They used chi(2) and Fisher exact tests to determine significant differences. They then performed molecular studies with genes in which mutations have been independently associated with both cancer and craniofacial anomalies in a total of 111 families with CL/P.

Results

The families with CL/P reported

SUBMITTER: Menezes R 

PROVIDER: S-EPMC2945901 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature