Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p.

ABSTRACT:

Background

GUP1 gene was primarily identified in Saccharomyces cerevisiae being connected with glycerol uptake defects in association with osmotic stress response. Soon after, Gup1p was implicated in a complex and extensive series of phenotypes involving major cellular processes. These include membrane and wall maintenance, lipid composition, bud-site selection, cytoskeleton orientation, vacuole morphology, secretory/endocytic pathway, GPI anchors remodelling, and lipid-ordered domains assembly, which is compatible with their inclusion in the Membrane Bound O-acyl transferases (MBOAT) family. In mammals, it has been described as a negative regulator of the Sonic hedgehog pathway involved in morphogenesis, differentiation, proliferation, among other processes.

Results

We show

SUBMITTER: Ferreira C 

PROVIDER: S-EPMC2945937 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature