Expression and localization of apolipoprotein M in human colorectal tissues.

ABSTRACT:

Background

It has been well documented that apolipoprotein M (apoM) is principally expressed in the liver and kidney. However we found that there was weak apoM expression in other tissues or organs too, which could not be ignored. In the present study, we therefore examined apoM expression in human colorectal tissues including cancer tissues, cancer adjacent normal tissues, polyp tissues and normal mucosa as well as inflammatory mucosa.

Methods

Tissue samples were collected from patients who underwent surgical resection or endoscopic examination. ApoM mRNA levels were determined by the real-time RT-PCR and apoM protein mass were examined by the immunohistochemistry.

Results

ApoM protein can be detected in all colorectal tissues. However, apoM protein mass were signifi

SUBMITTER: Luo G 

PROVIDER: S-EPMC2945960 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature