Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology.

ABSTRACT: Hypertension is the leading cause of cardiovascular diseases, and angiotensin II is one of the major components of the mechanisms that contribute to the development of hypertension. However, the precise mechanisms for the development of hypertension are unknown. Our recent study showing that angiotensin II-induced vascular smooth muscle cell growth depends on cytochrome P450 1B1 led us to investigate its contribution to hypertension caused by this peptide. Angiotensin II was infused via miniosmotic pump into rats (150 ng/kg per minute) or mice (1000 μg/kg per day) for 13 days resulting in increased blood pressure, increased cardiac and vascular hypertrophy, increased vascular reactivity to vasoconstrictor agents, increased vascular reactive oxygen species production, and endothelial dysfun

SUBMITTER: Jennings BL 

PROVIDER: S-EPMC2946077 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature