Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.

ABSTRACT: Epidemiologic studies suggest that type 2 diabetes (T2D) increases breast cancer risk and mortality, but there is limited experimental evidence supporting this association. Moreover, there has not been any definition of a pathophysiological pathway that diabetes may use to promote tumorigenesis. In the present study, we used the MKR mouse model of T2D to investigate molecular mechanisms that link T2D to breast cancer development and progression. MKR mice harbor a transgene encoding a dominant-negative, kinase-dead human insulin-like growth factor-I receptor (IGF-IR) that is expressed exclusively in skeletal muscle, where it acts to inactivate endogenous insulin receptor (IR) and IGF-IR. Although lean female MKR mice are insulin resistant and glucose intolerant, displaying accelerated mamma

SUBMITTER: Novosyadlyy R 

PROVIDER: S-EPMC2946167 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature