Mapping haplotype-haplotype interactions with adaptive LASSO.

ABSTRACT:

Background

The genetic etiology of complex diseases in human has been commonly viewed as a complex process involving both genetic and environmental factors functioning in a complicated manner. Quite often the interactions among genetic variants play major roles in determining the susceptibility of an individual to a particular disease. Statistical methods for modeling interactions underlying complex diseases between single genetic variants (e.g. single nucleotide polymorphisms or SNPs) have been extensively studied. Recently, haplotype-based analysis has gained its popularity among genetic association studies. When multiple sequence or haplotype interactions are involved in determining an individual's susceptibility to a disease, it presents daunting challenges in statistical model

SUBMITTER: Li M 

PROVIDER: S-EPMC2946267 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature