Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems.

ABSTRACT:

Background

The ability to selectively detect and target cancer cells that have undergone an epithelial-mesenchymal transition (EMT) may lead to improved methods to treat cancers such as pancreatic cancer. The remodeling of cellular glycosylation previously has been associated with cell differentiation and may represent a valuable class of molecular targets for EMT.

Methodology/principal findings

As a first step toward investigating the nature of glycosylation alterations in EMT, we characterized the expression of glycan-related genes in three in-vitro model systems that each represented a complementary aspect of pancreatic cancer EMT. These models included: 1) TGFβ-induced EMT, which provided a look at the active transition between states; 2) a panel of 22 pancreatic cancer

SUBMITTER: Maupin KA 

PROVIDER: S-EPMC2946336 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature