Trypanosomiasis-induced Th17-like immune responses in carp.

ABSTRACT:

Background

In mammalian vertebrates, the cytokine interleukin (IL)-12 consists of a heterodimer between p35 and p40 subunits whereas interleukin-23 is formed by a heterodimer between p19 and p40 subunits. During an immune response, the balance between IL-12 and IL-23 can depend on the nature of the pathogen associated molecular pattern (PAMP) recognized by, for example TLR2, leading to a preferential production of IL-23. IL-23 production promotes a Th17-mediated immune response characterized by the production of IL-17A/F and several chemokines, important for neutrophil recruitment and activation. For the cold blooded vertebrate common carp, only the IL-12 subunits have been described so far.

Methodology/principal findings

Common carp is the natural host of two protozoan para

SUBMITTER: Ribeiro CM 

PROVIDER: S-EPMC2946394 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature