Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles.

ABSTRACT: 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

SUBMITTER: Kwok SW 

PROVIDER: S-EPMC2946857 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature