EIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the main cause of dementia in our increasingly aging population. The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing illness for patients and carers. Although drugs have been developed to treat AD symptoms and to slow disease progression, there is currently no cure. The incidence of AD is predicted to increase to over one hundred million by 2050, placing a heavy burden on communities and economies, and making the development of effective therapies an urgent priority. Two proteins are thought to have major contributory roles in AD: the microtubule associated protein tau, also known as MAPT; and the amyloid-beta peptide (A-beta), a cleavage product of amyloid precursor protein (APP). Oxidative stress is also imp

SUBMITTER: Bottley A 

PROVIDER: S-EPMC2946912 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature