Age-correlated gene expression in normal and neurodegenerative human brain tissues.

ABSTRACT:

Background

Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors. Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by quantifying the similarities and differences in their genome-wide gene expression profiles.

Principal findings

We have developed a computational method for assessing an individual's "physiological brain age" by comparing global mRNA expression datasets across a range of normal human brain samples. Application of this method to brains samples from select regions in two diseases--Alzheimer's disease (AD, superior frontal gyrus), frontotemporal lobar degeneration (FTLD, in rostral aspect of

SUBMITTER: Cao K 

PROVIDER: S-EPMC2947518 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature