Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection.

ABSTRACT:

Unlabelled

Polymorphisms in the IL28B (interleukin-28B) gene region are important in predicting outcome following therapy for chronic hepatitis C virus (HCV) infection. We evaluated the role of IL28B in spontaneous and treatment-induced clearance following recent HCV infection. The Australian Trial in Acute Hepatitis C (ATAHC) was a study of the natural history and treatment of recent HCV, as defined by positive anti-HCV antibody, preceded by either acute clinical HCV infection within the prior 12 months or seroconversion within the prior 24 months. Factors associated with spontaneous and treatment-induced HCV clearance, including variations in IL28B, were assessed. Among 163 participants, 132 were untreated (n = 52) or had persistent infection (infection duration ≥26 weeks) at tre

SUBMITTER: Grebely J 

PROVIDER: S-EPMC2947598 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature