Effect of preventive (beta blocker) treatment, behavioural migraine management, or their combination on outcomes of optimised acute treatment in frequent migraine: randomised controlled trial.

ABSTRACT:

Objective

To determine if the addition of preventive drug treatment (β blocker), brief behavioural migraine management, or their combination improves the outcome of optimised acute treatment in the management of frequent migraine.

Design

Randomised placebo controlled trial over 16 months from July 2001 to November 2005.

Setting

Two outpatient sites in Ohio, USA.

Participants

232 adults (mean age 38 years; 79% female) with diagnosis of migraine with or without aura according to International Headache Society classification of headache disorders criteria, who recorded at least three migraines with disability per 30 days (mean 5.5 migraines/30 days), during an optimised run-in of acute treatment.

Interventions

Addition of one of four preventive treatments t

SUBMITTER: Holroyd KA 

PROVIDER: S-EPMC2947621 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature