Development of a new Lewis base-tolerant chiral LBA and its application to catalytic asymmetric protonation reaction.

ABSTRACT: A new Lewis base-tolerant LBA (Lewis Acid Assisted Brønsted Acid) derived from La(OTf)(3) and (S)-HOP has been developed as a new chiral Brønsted acid. This acid has been successfully applied as a catalyst to asymmetric protonation reactions of silyl enol ethers of 2-substituted cyclic ketones.

SUBMITTER: Cheon CH 

PROVIDER: S-EPMC2947798 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature