Tag-mass: specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag.

ABSTRACT: MALDI tissue imaging of tissues has become a promising technique for tracking biomarkers while determining their location and structural characterization. We have now developed specific targeting probes (oligonucleotides, antibodies), named Tag-Mass. This approach is based on probes modified with a photocleavable linker coupled with a tag cleaved and detected using mass spectrometry. Tag-Mass development is the key for a rapid, sensitive, and accurate approach to correlate levels of expression of different mRNA or proteins in diseases.

SUBMITTER: Lemaire R 

PROVIDER: S-EPMC2947822 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature